:root { color-scheme: light; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Arial, sans-serif; color: #283139; background: #fff; font-size: 16px; line-height: 1.5; }
* { box-sizing: border-box; }
body { margin: 0; }
a { color: #206697; text-underline-offset: 3px; }
a:hover { color: #124465; }
header { border-bottom: 1px solid #e1e4e7; }
nav { max-width: 1000px; min-height: 65px; padding: 12px 24px; margin: auto; display: flex; align-items: center; justify-content: space-between; gap: 24px; }
nav div { display: flex; gap: 24px; flex-wrap: wrap; }
nav a { color: #3b4348; text-decoration: none; font-size: 16px; }
nav a:hover { text-decoration: underline; }
.wordmark { font-size: 18px; font-weight: 650; color: #315770; }
main { max-width: 760px; padding: 0 24px; margin: auto; }
section { border-bottom: 1px solid #dfe3e6; padding: 29px 0 32px; text-align: center; scroll-margin-top: 20px; }
.introduction { padding-top: 34px; }
.mark { display: block; width: 216px; height: 168px; margin: 0 auto 12px; }
h1 { margin: 0; font-size: 40px; line-height: 1.2; font-weight: 500; letter-spacing: -.6px; }
.subtitle { margin: 0 0 23px; font-size: 28px; font-weight: 400; }
h3 { margin: 0 0 10px; font-size: 20px; font-weight: 500; }
p { margin: 10px 0 16px; }
hr { height: 1px; border: 0; background: #dfe3e6; margin: 25px 0; }
.small { font-size: 14px; color: #57616a; }
.notice { font-size: 14px; text-align: left; padding: 12px 15px; border-left: 3px solid #a9bac6; background: #f5f7f9; margin-bottom: 0; }
button { appearance: none; border: 1px solid #216ba0; border-radius: 3px; background: #216ba0; color: #fff; font: inherit; font-size: 16px; padding: 9px 22px; cursor: pointer; }
button:hover:not(:disabled) { background: #19547e; border-color: #19547e; }
button:disabled { background: #edf0f2; color: #6a747c; border-color: #d5dce1; cursor: not-allowed; }
#setup { display: block; margin-inline: auto; }
.status { font-size: 14px; color: #57616a; margin-bottom: 4px; overflow-wrap: anywhere; }
.status::before { content: ""; display: inline-block; width: 7px; height: 7px; border-radius: 50%; background: #b29447; margin-right: 7px; }
.status.ready::before { background: #468163; }
.error { background: #fff3f1; border: 1px solid #dcb5ae; color: #8b3023; text-align: left; padding: 12px; font-size: 16px; overflow-wrap: anywhere; }
.form { text-align: left; margin-top: 24px; }
label { display: block; font-size: 16px; font-weight: 550; }
.label-row { display: flex; align-items: baseline; justify-content: space-between; gap: 12px; margin: 8px 0; }
.text-button { padding: 5px 10px; }
textarea, select, input[type="number"], input[type="text"] { width: 100%; border: 1px solid #aebbc5; border-radius: 3px; padding: 10px 12px; color: #283139; background: #fff; font: inherit; }
textarea { display: block; min-height: 140px; resize: vertical; font: 16px/1.5 ui-monospace, Consolas, monospace; }
.folder-path { margin: 6px 0 14px; font-family: ui-monospace, Consolas, monospace !important; background: #f5f7f9 !important; }
.file-label { font-size: 16px; font-weight: 400; padding: 12px 0 23px; }
input[type="file"] { display: block; width: 100%; margin-top: 6px; font: inherit; }
select { margin-top: 7px; }
.form details { margin-top: 20px; }
details { text-align: left; padding: 11px 0; border-top: 1px solid #e7ebee; }
summary { cursor: pointer; font-size: 16px; font-weight: 600; }
details p { font-size: 16px; margin: 10px 0 0; }
.technical { margin-top: 18px; }
pre { font: 13px/1.5 ui-monospace, Consolas, monospace; white-space: pre-wrap; overflow-wrap: anywhere; background: #f5f7f9; padding: 12px; }
.settings { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; padding-top: 12px; }
.settings input { margin-top: 6px; }
.actions { display: flex; justify-content: center; flex-wrap: wrap; gap: 12px; margin-top: 24px; }
progress { width: 100%; height: 7px; accent-color: #216ba0; margin-top: 12px; }
.image-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 28px; max-width: 560px; margin: 25px auto; }
figure { margin: 0; }
.image-frame { aspect-ratio: 1; background: #f5f7f9; border: 1px solid #dfe4e8; display: flex; align-items: center; justify-content: center; color: #75828c; font-size: 14px; }
.image-frame img, .image-frame canvas { width: 100%; height: auto; display: block; }
figcaption { font-size: 16px; margin-top: 11px; }
figcaption span { display: block; font-size: 14px; color: #65717b; }
.channel-key span { display: inline; }
.channel-key .nucleus-key { color: #245bba; }
.channel-key .microtubules-key { color: #a93939; }
.channel-key .er-key { color: #8a6800; }
.model-table { width: 100%; border-collapse: collapse; font-size: 16px; margin: 18px 0; }
.model-table caption { text-align: left; color: #57616a; padding: 6px 0; font-size: 14px; }
.model-table th, .model-table td { text-align: left; padding: 8px 10px; border-bottom: 1px solid #e2e6e9; }
.model-table thead { background: #f5f7f9; }
.lookup-row { display: flex; gap: 10px; margin-top: 8px; }
.lookup-row input { min-width: 0; }
.lookup-row button { flex-shrink: 0; }
.uniprot-lookup { border-bottom: 1px solid #e2e6e9; margin-bottom: 20px; }
.reference-selectors { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; }
.reference-selectors > div { display: flex; flex-direction: column; justify-content: space-between; }
.reference-preview { max-width: 256px; margin: 20px auto; text-align: center; }
.reference-preview figcaption { font-size: 14px; }
@media (max-width: 420px) { .model-table th, .model-table td { padding: 7px 4px; } .lookup-row { flex-wrap: wrap; } .reference-selectors { gap: 12px; } }
footer { padding: 24px 0 35px; text-align: center; font-size: 13px; color: #6a747c; }
footer p { margin: 6px 0; }
footer .small { font-size: inherit; }
[hidden] { display: none !important; }
:focus-visible { outline: 3px solid #548bb4; outline-offset: 3px; }
.skip-link { position: absolute; top: -60px; left: 12px; background: white; padding: 10px; z-index: 1; }
.skip-link:focus { top: 8px; }
@media (max-width: 640px) { h1 { font-size: 34px; } .subtitle { font-size: 23px; } }
@media (max-width: 560px) { nav { flex-direction: column; gap: 10px; padding: 12px 16px; } nav div { gap: 18px; justify-content: center; } main { padding: 0 18px; } .label-row { flex-wrap: wrap; gap: 3px; } .image-grid { gap: 14px; } .settings { gap: 12px; } }